Lack of Sleep and Chronic Diseases
Scientific References
Lack of Sleep and Chronic Diseases
News Review


Scientific References

Effects of a Good Sleep
Sleep, Disease Risks and Mortality
Sleep and Alzheimer’s Disease
Sleep and Cardiovascular Disease
Sleep and Other Diseases


Resources and Links

Worldwide
Canada
USA



News Review

Scientists Finding Out What Losing Sleep Does to a Body
By Rob Stein, Washington Post Staff Writer
Sunday, October 9, 2005
[Article]



Scientific References

Positive affect, psychological well-being, and good sleep.
Steptoe A, O'Donnell K, Marmot M, Wardle J.
J Psychosom Res. 2008 Apr;64(4):409-15.
[Abstract]

Positive well-being and sleep. Roberts RE, J Psychosom Res. 2008 Apr;64(4):417-8.



Sleep, Disease Risks and Mortality


Sleep and society: an epidemiological perspective.
Bixler E. Sleep Med. 2009 Sep;10 Suppl 1:S3-6.
[Abstract]


The public health and safety consequences of sleep disorders, Sigurdson K, Ayas. Canadian J Physiol Pharmacol. 85:179-183.
doi:10.1139/Y06-095
[Abstract][Full text][Full Text PDF]


Sleep and mortality: a population-based 22-year follow-up study, Hublin C, Partinen M, Koskenvuo M, Kaprio J. Sleep. 2007 Oct 1;30(10):1245-53.
[Abstract]


Sleep duration and all-cause mortality: a systematic review and meta-analysis of prospective studies.
Cappuccio FP, D'Elia L, Strazzullo P, Miller MA. Sleep. 2010 May 1;33(5):585-92.
[Abstract]


Sleep duration and mortality: a systematic review and meta-analysis.
Gallicchio L, Kalesan B. J Sleep Res. 2009 Jun;18(2):148-58.
[Abstract]


Mortality associated with sleep duration and insomnia.
Kripke DF, Garfinkel L, Wingard DL, Klauber MR, Marler MR.
Arch Gen Psychiatry. 2002 Feb;59(2):131-6.
[Abstract]


A prospective study of sleep duration and mortality risk in women, Patel SR, Ayas NT, Malhotra MR, White DP, Schernhammer ES, Speizer FE, Stampfer MJ, Hu FB. Sleep. 2004 May 1;27(3):440-4.
[Abstract]



Sleep and Alzheimer’s Disease

Amyloid-β dynamics are regulated by orexin and the sleep-wake cycle.
Jae-Eun Kang, Miranda M. Lim, Randall J. Bateman, James J. Lee, Liam P. Smyth, John R. Cirrito, Nobuhiro Fujiki, Seiji Nishino, David M. Holtzman
Science 326, 1005–1007 (2009).
[Abstract]

  • Abstract: Amyloid-β (Aβ) accumulation in the brain extracellular space is a hallmark of Alzheimer’s disease. The factors regulating this process are only partly understood. Aβ aggregation is a concentration-dependent process that is likely responsive to changes in brain interstitial fluid (ISF) levels of Aβ. Using in vivo microdialysis in mice, we found that the amount of ISF Aβ correlated with wakefulness. The amount of ISF Aβ also significantly increased during acute sleep deprivation and during orexin infusion, but decreased with infusion of a dual orexin receptor antagonist. Chronic sleep restriction significantly increased, and a dual orexin receptor antagonist decreased, Aβ plaque formation in amyloid precursor protein transgenic mice. Thus, the sleep-wake cycle and orexin may play a role in the pathogenesis of Alzheimer’s disease.



Sleep and Cardiovascular Diseases

Sleep duration and risk of ischemic stroke in postmenopausal women.
Chen JC, Brunner RL, Ren H, Wassertheil-Smoller S, Larson JC, Levine DW, Allison M, Naughton MJ, Stefanick ML., Stroke. 2008 Dec;39(12):3185-92. Epub 2008 Jul 17.
[Abstract]


Habitual sleep duration and insomnia and the risk of cardiovascular events and all-cause death: report from a community-based cohort.
Chien KL, Chen PC, Hsu HC, Su TC, Sung FC, Chen MF, Lee YT.
Sleep. 2010 Feb 1;33(2):177-84.
[Abstract]


Inflammatory aspects of sleep apnea and their cardiovascular consequences, Kasasbeh E, Chi DS, Krishnaswamy G. South Med J 2006;99:58–67.
[Full Text][Full Text PDF]


Association of sleep duration with mortality from cardiovascular disease and other causes for Japanese men and women: the JACC study.
Ikehara S, Iso H, Date C, Kikuchi S, Watanabe Y, Wada Y, Inaba Y, Tamakoshi A; JACC Study Group. Sleep. 2009 Mar 1;32(3):295-301.
[Abstract]


Habitual sleep patterns and risk for stroke and coronary heart disease: a 10-year follow-up from NHANES I., Qureshi AI, Giles WH, Croft JB, Bliwise DL. Neurology. 1997 Apr;48(4):904-11.
[Abstract]



Sleep and Other Diseases

 
Role of sleep duration and quality in the risk and severity of type 2 diabetes mellitus. Knutson KL, Ryden AM, Mander VA, Van Cauter E. Arch Intern Med 2006;166:1768–1774.
[Abstract][Full Text][Full Text PDF]
 
Symptoms of depression in individuals with obstructive sleep apnea may be amenable to treatment with continuous positive airway pressure. Schwartz DJ, Kohler WC, Karatinos G. Chest  2005;128:1304–1306.
doi: 10.1378/chest.128.3.1304
[Abstract][Full Text][Full Text PDF]

The link between short sleep duration and obesity: We should recommend more sleep to prevent obesity, Taheri S. Arch Dis Child 2006;91:881–884.
[Abstract]
 


Resources

Important Notice: Links to external organizations are provided for information only. Please read our External Links Policy.


Worldwide
Canada
USA


Worldwide

World Federation of Sleep Research & Sleep Medicine Societies



Canada

Canadian Sleep Society
C/O Canadian Sleep Society / Socié̩té̩̩ Canadienne du Sommeil
4994 de Maisonneuve O., Suite 103
Westmount, Québec, Canada
H3Z 3B9
Telephone: 514 509 2113
Fax: 514 509 2114

Fondation Sommeil
1600, avenue de Lorimier
Montréal, QC Canada
Phone Number: (514) 522-3901
Fax Number: (514) 522-0274
Toll Free Number: 1-888-622-3901

The Lung Association - Sleep Apnea LASA
c\o 911 -78 Ave SW
Calgary, AB Canada
Phone Number: 403-270-9352
Fax Number: 403-206-7552
Toll Free Number: 1-800-817-5337
Website: www.sleep-apnea.ab.ca

Sleep Medicine Clinics in Canada
(Please refer to the Canadian Sleep Society Website)


USA

National Sleep Foundation
1522 K Street, NW, Suite 500
Washington, DC 20005
Phone (202) 347-3471
Fax (202) 347-3472  
E-mail nsf@sleepfoundation.org
Sleep for Kids
See National Sleep Foundation

American Academy of Sleep Medicine
2510 N. Frontage Road
Darien, Illinois 60561
 
American Insomnia Association
1 Westbrook Corporate Center
Suite 920
Westchester, IL 60154
 
American Sleep Apnea Association
6856 Eastern Avenue, NW Ste. 203
Washington, DC 20012-2119
 
Drowsy Driving
 
Narcolepsy Network, Inc.
P.O. Box 294
Pleasantville, NY 10570
 
Restless Legs Syndrome Foundation
1610 14th St, NW
Suite 400
Rochester, MN 55901
 
Sleep Research Society
1Westbrook Corporate Square
Westchester, IL 60154

Center for Disease Control (US): http://www.cdc.gov/sleep/chronic_disease.htm