Micronutrients and Inflammatory Diseases
Scientific References

Role of specific micronutrients in the prevention and treatment of inflammatory diseases


Dietary modification of inflammation with lipids. Calder PC. Proc Nutr Soc. 2002;61(3):345-358. 
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gamma-Linolenic acid treatment of rheumatoid arthritis. A randomized, placebo-controlled trial. Zurier RB, Rossetti RG, Jacobson EW, et al. Arthritis Rheum. 1996;39(11):1808-1817. 
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Alpha-linolenic acid in the treatment of rheumatoid arthritis. A double-blind, placebo-controlled and randomized study: flaxseed vs. safflower seed. Nordstrom DC, Honkanen VE, Nasu Y, Antila E, Friman C, Konttinen YT. Rheumatol Int. 1995;14(6):231-234. 
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Fatty acids, the immune response, and autoimmunity: a question of n-6 essentiality and the balance between n-6 and n-3. Harbige LS. Lipids. 2003;38(4):323-341. 
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Polyunsaturated fatty acids and inflammation. Calder PC. Prostaglandins Leukot Essent Fatty Acids. 2006;75(3):197-202. 
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Validation of a meta-analysis: the effects of fish oil in rheumatoid arthritis. Fortin PR, Lew RA, Liang MH, et al. J Clin Epidemiol. 1995;48(11):1379-1390.  [Abstract]

A meta-analysis of the analgesic effects of omega-3 polyunsaturated fatty acid supplementation for inflammatory joint pain. Goldberg RJ, Katz J. Pain. 2007;129(1-2):210-223. 
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Supplementation with n-3 fatty acids from fish oil in chronic inflammatory bowel disease--a randomized, placebo-controlled, double-blind cross-over trial. Lorenz R, Weber PC, Szimnau P, Heldwein W, Strasser T, Loeschke K. J Intern Med Suppl. 1989;225(731):225-232. 
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Omega-3 fatty acids and low carbohydrate diet for maintenance of remission in Crohn's disease. A randomized controlled multicenter trial. Study Group Members (German Crohn's Disease Study Group). Lorenz-Meyer H, Bauer P, Nicolay C, et al. Scand J Gastroenterol. 1996;31(8):778-785.
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Effect of an enteric-coated fish-oil preparation on relapses in Crohn's disease. Belluzzi A, Brignola C, Campieri M, Pera A, Boschi S, Miglioli M. N Engl J Med. 1996;334(24):1557-1560. 
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Usefulness of omega-3 fatty acid supplementation in addition to mesalazine in maintaining remission in pediatric Crohn's disease: a double-blind, randomized, placebo-controlled study. Romano C, Cucchiara S, Barabino A, Annese V, Sferlazzas C. World J Gastroenterol. 2005;11(45):7118-7121. 
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Fish oil fatty acid supplementation in active ulcerative colitis: a double-blind, placebo-controlled, crossover study. Aslan A, Triadafilopoulos G. Am J Gastroenterol. 1992;87(4):432-437. 
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Treatment of ulcerative colitis with fish oil supplementation: a prospective 12 month randomised controlled trial. Hawthorne AB, Daneshmend TK, Hawkey CJ, et al. Gut. 1992;33(7):922-928. 
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Dietary supplementation with fish oil in ulcerative colitis. Stenson WF, Cort D, Rodgers J, et al. Ann Intern Med. 1992;116(8):609-614. 
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n-3 fatty acids only delay early relapse of ulcerative colitis in remission. Loeschke K, Ueberschaer B, Pietsch A, et al. Dig Dis Sci. 1996;41(10):2087-2094. 
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Fish oil for induction of remission in ulcerative colitis. De Ley M, de Vos R, Hommes DW, Stokkers P. Cochrane Database Syst Rev. 2007;(4):CD005986.  [Abstract]

Effect of dietary intake of omega-3 and omega-6 fatty acids on severity of asthma in children. Hodge L, Salome CM, Hughes JM, et al. Eur Respir J. 1998;11(2):361-365. 
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Effects of dietary supplementation with n-3 fatty acids compared with n-6 fatty acids on bronchial asthma. Okamoto M, Mitsunobu F, Ashida K, et al. Intern Med. 2000;39(2):107-111. 
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Clinical efficacy of n-3 fatty acid supplementation in patients with asthma. Wong KW. J Am Diet Assoc. 2005;105(1):98-105. 
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Health effects of omega-3 fatty acids on asthma. Schachter HM, Reisman J, Tran K, et al. Evid Rep Technol Assess (Summ). 2004(91):1-7. 
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Dietary marine fatty acids (fish oil) for asthma in adults and children. Woods RK, Thien FC, Abramson MJ. Cochrane Database Syst Rev. 2002(3):CD001283. 
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Treating asthma with omega-3 fatty acids: where is the evidence? A systematic review. Reisman J, Schachter HM, Dales RE, et al. BMC Complement Altern Med. 2006;6:26. 
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