Scientific References - Nutrition and Ageing
Nutrition, calorie intake and ageing
Energy Intake, Meal Frequency and Health: A Neurobiological Perspective
Mark P. Mattson, Annual Review of Nutrition, Vol. 25: 237-260
[Abstract]
Longevity increased by positive self-perceptions of aging
Levy BR, Slade MD, Kunkel SR, Kasl SV.
Journal of personality and social psychology, 2002 Aug; 83(2): 261-70.
[Abstract]
Caloric restriction and aging: studies in mice and monkeys
Anderson, M.; Shanmuganayagam, D.; Weindruch, R. (2009).
Toxicologic pathology 37 (1): 47–51. DOI: 10.1177/0192623308329476
Metabolic shifts due to long-term caloric restriction revealed in nonhuman primates, Rezzi S, Martin FP, Shanmuganayagam D, Colman RJ, Nicholson JK, Weindruch R, Experimental Gerontology 44 (5): 356–62. (May 2009), doi:10.1016/j.exger.2009.02.008
[Abstract]
Aging, adiposity, and calorie restriction
Fontana, L.; Klein, S. (2007),
Journal of the American Medical Association 297 (9): 986–994.
Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans
Fontana L, Weiss EP, Villareal DT, Klein S, Holloszy JO
Aging Cell, 7 (5): 681–687. (2008)
[Abstract]
The anti-ageing effects of caloric restriction may involve stimulation of macroautophagy and lysosomal degradation, and can be intensified pharmacologically
Bergamini E, Cavallini G, Donati A, Gori Z
Biomedecine & Pharmacotherapy, 57 (5-6): 203–8. (2003).
[Abstract]
Autophagy and aging: the importance of maintaining "clean" cells
Cuervo AM, Bergamini E, Brunk UT, Dröge W, Ffrench M, Terman A
Autophagy, Volume1, Essue 3: 131–140. (2005).
Some Try Calorie Restriction For Long Life
Elisa Zied
MSNBC, Oct 5, 2007
[Article]
Caloric restriction improves memory in elderly humans
Witte, A. V.; M. Fobker, R. Gellner, S. Knecht, and A. Flöel, Proceedings of the National Academy of Sciences, January 27, 2009 vol. 106 no. 4 1255-1260
Cutting calories 'boosts memory’
BBC News. 27 January 2009.
[Article]
Midlife and Late-Life Obesity and the Risk of Dementia Cardiovascular Health Study, Annette L. Fitzpatrick, PhD; Lewis H. Kuller, MD, DrPH; Oscar L. Lopez, MD; Paula Diehr, PhD; Ellen S. O’Meara, PhD; W. T. Longstreth Jr, MD, MPH; José A. Luchsinger, MD, MPH., Archives of Neurology,. 2009;66(3):336-342.
Attenuation of sarcopenia by dietary restriction in rhesus monkeys
Colman, Rj; Beasley, Tm; Allison, Db; Weindruch, R (Jun 2008).
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2008 Jun;63(6):556-9
Cause-Specific Excess Deaths Associated With Underweight, Overweight, and Obesity, Flegal, Katherine M.; Barry I. Graubard, David F. Williamson, Mitchell H. Gail (PDF). The Journal of the American Medical Association, 298 (17): 2028–2037. [Abstract][Full Text][Full Text PDF]
Dietary restriction and aging in rhesus monkeys: the University of Wisconsin study, Ramsey JJ, Colman RJ, Binkley NC, Christensen JD, Gresl TA, Kemnitz JW, Weindruch R., Experimental Gerontology, 2000 Dec;35(9-10):1131-49.
Calorie restriction attenuates Alzheimer's disease type brain amyloidosis in Squirrel monkeys (Saimiri sciureus).
Qin W, Chachich M, Lane M, Roth G, Bryant M, de Cabo R, Ottinger MA, Mattison J, Ingram D, Gandy S, Pasinetti GM.,
Journal of Alzheimer’s Disease, 2006 Dec;10(4):417-22.
[Abstract]
Caloric restriction reduces cell loss and maintains estrogen receptor-alpha immunoreactivity in the pre-optic hypothalamus of female B6D2F1 mice
Yaghmaie F, Saeed O, Garan SA, Freitag W, Timiras PS, Sternberg H.
Neuroendocrinology Letters, 2005 Jun; Vol. 26(3):197-203.
[Abstract]
Insulin-like growth factor-1 receptor immunoreactive cells are selectively maintained in the paraventricular hypothalamus of calorically restricted mice
Saeed O, Yaghmaie F, Garan SA, Gouw AM, Voelker MA, Sternberg H, Timiras PS.
International Journal of Developmental Neuroscience, 25 (1): 23–8. doi:10.1016/j.ijdevneu.2006.11.004
[Abstract]
Age-dependent loss of insulin-like growth factor-1 receptor immunoreactive cells in the supraoptic hypothalamus is reduced in calorically restricted mice
Yaghmaie F, Saeed O, Garan SA, Voelker MA, Gouw AM, Freitag W, Sternberg H, Timiras PS
International Journal of Developmental Neuroscience, 24 (7): 431–6. doi:10.1016/j.ijdevneu.2006.08.008
[Abstract]
Recent Developments in Yeast Aging
Kaeberlein, M., Burtner, C.R., and Kennedy, B.K.
PLoS Genetics, 3, e84.
Calorie restriction and the nutrient sensing signaling pathways
Dilova, I., Easlon, E., and Lin, S.
Cellular and Molecular Life Sciences, 64, 752-767.
[Abstract]
SIR2: a potential target for calorie restriction mimetics
Chen, D., and Guarente, L.
Trends in Molecular Medicine, 13, 64-71.
[Abstract]
Long-lived yeast as a model for ageing research.
Piper, P.W.
Yeast 23, 215-226.
[Abstract]
Linking sirtuins, IGF-I signaling, and starvation
Longo, V.D.
Experimental Gerontology, 44, 70-74.
[Abstract]
Demography of dietary restriction and death in Drosophila
Mair W, Goymer P, Pletcher SD, Partridge L.
Science, 2003 Sep 19;301(5640):1731-3.
[Abstract]
Glucose Restriction Extends Caenorhabditis elegans Life Span by Inducing Mitochondrial Respiration and Increasing Oxidative Stress
Schulz et al.
Cell Metabolism, 6 (4): 280–293.
[Abstract]
Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans
Fontana L, Meyer TE, Klein S, Holloszy JO.
Proceedings of the National Academy of Sciences, U.S.A. 101 (17): 6659–63.
Mimetics of caloric restriction include agonists of lipid-activated nuclear receptors
Corton JC, Apte U, Anderson SP, et al. (October 2004).
The Journal of Biological Chemistry, 279 (44): 46204–12. doi:10.1074/jbc.M406739200
Extrachromosomal rDNA circles--a cause of aging in yeast
Sinclair DA, Guarente L.
Cell, 1997 Dec 26;91(7):1033-42.
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B, Howitz KT, Gorospe M, de Cabo R, Sinclair DA.
Science, 2004 Jul 16;305(5682):390-2. Epub 2004 Jun 17.
[Abstract]
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma.
Picard F, Kurtev M, Chung N, et al.
Nature, 2004 Jun 17;429(6993):771-6.
[Abstract]
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.
Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA.
Nature, 2003 Sep 11;425(6954):191-6. Epub 2003 Aug 24.
[Abstract]
Resveratrol improves health and survival of mice on a high-calorie diet.
Baur JA, et al
Nature, 2006 Nov 16;444(7117):337-42. Epub 2006 Nov 1.
[Abstract]
Resveratrol Prolongs Lifespan and Retards the Onset of Age-Related Markers in a Short-Lived Vertebrate
Dario R. Valenzano1, Eva Terzibasi2, Tyrone Genade2, Antonino Cattaneo3, 4, Luciano Domenici2, 5 and Alessandro Cellerino1, 2
Current Biology, Volume 16, Issue 3, 296-300, 7 February 2006
Sir2-independent life span extension by calorie restriction in yeast.
Kaeberlein M, Kirkland KT, Fields S, Kennedy BK.
PLoS Biology, 2004 Sep;2(9):E296. Epub 2004 Aug 24.
SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging.
Oberdoerffer, P., Michan, S., McVay, M., Mostoslavsky, R., Vann, J., Park, S.-K., Hartlerode, A., Stegmuller, J., Hafner, A., Loerch, P., et al. (2008).
Cell, Volume 135, Issue 5, 907-918, 28 November 2008 doi:10.1016/j.cell.2008.10.025
Sir2 Blocks Extreme Life-Span Extension.
Fabrizio, P., Gattazzo, C., Battistella, L., Wei, M., Cheng, C., McGrew, K., and Longo, V.D. (2005).
Cell, Volume 123, Issue 4, 655-667, 18 November 2005 doi:10.1016/j.cell.2005.08.042
SirT1 Inhibition Reduces IGF-I/IRS-2/Ras/ERK1/2 Signaling and Protects Neurons.
Li, Y., Xu, W., McBurney, M.W., and Longo, V.D. (2008).
Cell Metabolism, Volume 8, Issue 1, 38-48, 2 July 2008 doi:10.1016/j.cmet.2008.05.004
Sir2 and calorie restriction in yeast: A skeptical perspective.
Kaeberlein, M., and Powers Iii, R.W. (2007).
Ageing Research Reviews, Volume 6, Issue 2, August2007, Pages 128-140 doi:10.1016/j.arr.2007.04.001
[Abstract]
Short-Term Calorie Restriction in Male Mice Feminizes Gene Expression and Alters Key Regulators of Conserved Aging Regulatory Pathways
Estep, P. W.; Warner, J. B.; Bulyk, M. L.; Orban, L. (2009).
PLoS ON, 4: e5242.
Calorie restriction and the exercise of chromatin
Vaquero, A.; Reinberg, D. (2009).
Genes & Development, 23: 1849.
Effect of caloric restriction on life span of the housefly, Musca domestica.
Cooper TM, Mockett RJ, Sohal BH, Sohal RS, Orr WC.
The Federation of American Societies for Experimental Biology Journal, 2004 Oct;18(13):1591-3. Epub 2004 Aug 19
Calorie Restriction Appears Better Than Exercise At Slowing Primary Aging.
Washington University School of Medicine.
ScienceDaily, 31 May 2006. 24 April 2009
[Article]
Is late-life caloric restriction beneficial?
Lipman RD, Smith DE, Bronson RT, Blumberg J.
Aging (Milano), 1995 Apr;7(2):136-9.
[Abstract]
Rapid and reversible induction of the longevity, anticancer and genomic effects of caloric restriction.
Spindler SR.
Mechanisms of Ageing and Development, 2005 Sep;126(9):960-6. Review.
[Abstract]
Caloric restriction transiently improves motor performance but hastens clinical onset of disease in the Cu/Zn-superoxide dismutase mutant G93A mouse.
Hamadeh MJ, Rodriguez MC, Kaczor JJ, Tarnopolsky MA.
Muscle & Nerve, 2005 Feb;31(2):214-20.
[Abstract]
Nutritional status of patients with amyotrophic lateral sclerosis: relation to the proximity of death.
Kasarskis EJ, Berryman S, Vanderleest JG, Schneider AR, McClain CJ.
American Journal of Clinical Nutrition, 1996 Jan;63(1):130-7.
Nutritional considerations in the management of patients with amyotrophic lateral sclerosis (ALS).
Slowie LA, Paige MS, Antel JP.
Journal of the American Dietetic Association, 1983 Jul;83(1):44-7.
[Abstract]
A ketogenic diet as a potential novel therapeutic intervention in amyotrophic lateral sclerosis.
Zhao Z, Lange DJ , Voustianiouk A, et al.
BMC Neuroscience, 2006, 7:29
Why dietary restriction substantially increases longevity in animal models but won't in humans.
Phelan JP, Rose
Ageing Research Reviews., 2005 Aug;4(3):339-50. Doi: 10.1016/j.arr.2005.06.001
[Abstract]
Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake.
R. Michael Anson, Zhihong Guo, Rafael de Cabo, Titilola Iyun, Michelle Rios, Adrienne Hagepanos, Donald K. Ingram, Mark A. LaneDagger, Mark P. Mattson.
Proceedings of the National Academy of Sciences, May 13, 2003, vol. 100, no. 10, 6216-6220
Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthma.
Johnson JB, Summer W, Cutler RG, Martin B, Hyun DH, Dixit VD, Pearson M, Nassar M, Tellejohan R, Maudsley S, Carlson O, John S, Laub DR, Mattson MP.
Free Radical Biology & Medicine, 2007 Mar 1;42(5):665-74. Epub 2006 Dec 14.
[Abstract]
The effect on health of alternate day calorie restriction: eating less and more than needed on alternate days prolongs life.
Johnson JB, Laub DR, John S.
Medical Hypotheses, 2006;67(2):209-11. Epub 2006 Mar 10.
[Abstract]
How does calorie restriction work?
Jana Koubova and Leonard Guarente
Genes & Development, 17(3):313-321 (2003)
The Retardation of Aging and Disease by Dietary Restriction
Richard Weindruch, Roy L. Walford
Charles C Thomas Pub Ltd (December 1988)
Ageless Quest.
Lenny Guarente,
Cold Spring Harbor Press, NY. 2003.
The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake.
Weindruch R, et al
Journal of Nutrition, 116(4), pages 641-54., April, 1986.
Caloric Restriction and Aging
Richard Weindruch
Scientific American, Vol. 274, No. 1, pages 46–52; January 1996.
[Abstract]
Biomarkers of caloric restriction may predict longevity in humans.
Roth GS, Lane MA, Ingram DK, Mattison JA, Elahi D, Tobin JD, Muller D, Metter EJ.
Science, 2002 Aug 2;297(5582):811.
[Abstract]
Eat more, weigh less, live longer
Philip Cohen
New Scientist, 23 January 2003.
[Article]
Extended longevity in mice lacking the insulin receptor in adipose tissue.
Bluher, Khan BP, Kahn CR,
Science, 299(5606): 572-4, 24 January 2003.
[Abstract]
"I want to live forever"
Interview: Cynthia Kenyon, Professor of Biochemistry and Biophysics at the University of California, San Francisco, by James Kingsland
New Scientist online, 20 October 2003.
[Abstract]
Sir2-independent life span extension by calorie restriction in yeast
Kaeberlein, M., K.T. Kirkland, S. Fields, and B.K. Kennedy
PLoS Biology, 2004 Sep; 2(9):E296. Epub 2004 Aug 24.
Substrate-specific Activation of Sirtuins
by Resveratrol, Kaeberlein, M., T. McDonagh, B. Heltweg, J. Hixon, E.A. Westman, S.D. Caldwell, A. Napper, R. Curtis, P.S. Distefano, S. Fields, A. Bedalov, and B.K. Kennedy. 2005.
The Journal of Biological Chemistry, 280: 17038-45.
Increased Life Span due to Calorie Restriction in Respiratory-Deficient Yeast
Kaeberlein M, Hu D, Kerr EO, Tsuchiya M, Westman EA, Dang N, Fields S, Kennedy BK., PLoS Genetics, 25 November 2005;1(5):e69
Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients
Kaeberlein M, Powers RW 3rd, Steffen KK, Westman EA, Hu D, Dang N, Kerr EO, Kirkland KT, Fields S, Kennedy BK.
Science, 18 November 2005;310(5751):1193-6.
[Abstract]
PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans
Siler H. Panowski, Suzanne Wolff, Hugo Aguilaniu, Jenni Durieux & Andrew Dillin. 2 May 2007.
Nature, 447, 550-555 (31 May 2007)
[Abstract]
Fasting fosters longevity in rats.
Science News, Vol. 116, No. 22: 375, 1 December 1979.
[Abstract]
News
The gene for longevity, if you're a worm
Marlowe Hood
ABC News, 2007.
Longevity gene linked to low-calorie diets
Vergano, Dan (3 May 2007).
USA Today.
[Article]
Dieting Moneys Offer Hope for Living Longer
Wade, Nicholas
New York Times. (10 July 2009).
[Article]
The Calorie-Restriction Experiment
Gertner, Jon
The New York Times Magazine. (2009-10-07).
[Article]
Reduced Diet Thwarts Aging, Disease In Monkeys
Science Daily, July 10, 2009
[Article]
Abstract
The size and frequency of meals are fundamental aspects of nutrition that can have profound effects on the health and longevity of laboratory animals. In humans, excessive energy intake is associated with increased incidence of cardiovascular disease, diabetes, and certain cancers and is a major cause of disability and death in industrialized countries. On the other hand, the influence of meal frequency on human health and longevity is unclear. Both caloric (energy) restriction (CR) and reduced meal frequency/intermittent fasting can suppress the development of various diseases and can increase life span in rodents by mechanisms involving reduced oxidative damage and increased stress resistance. Many of the beneficial effects of CR and fasting appear to be mediated by the nervous system. For example, intermittent fasting results in increased production of brain-derived neurotrophic factor (BDNF), which increases the resistance of neurons in the brain to dysfunction and degeneration in animal models of neurodegenerative disorders; BDNF signaling may also mediate beneficial effects of intermittent fasting on glucose regulation and cardiovascular function. A better understanding of the neurobiological mechanisms by which meal size and frequency affect human health may lead to novel approaches for disease prevention and treatment.
Abstract
This research found that older individuals with more positive self-perceptions of aging, measured up to 23 years earlier, lived 7.5 years longer than those with less positive self-perceptions of aging. This advantage remained after age, gender, socioeconomic status, loneliness, and functional health were included as covariates. It was also found that this effect is partially mediated by will to live. The sample consisted of 660 individuals aged 50 and older who participated in a community-based survey, the Ohio Longitudinal Study of Aging and Retirement (OLSAR). By matching the OLSAR to mortality data recently obtained from the National Death Index, the authors were able to conduct survival analyses. The findings suggest that the self-perceptions of stigmatized groups can influence longevity.
